Can anti-Mullerian hormone (AMH) predict the outcome of intrauterine insemination with controlled ovarian stimulation?

Abstract

Objective: To assess whether the levels of anti-Mullerian hormone (AMH) are related to outcome of intrauterine insemination (IUI) in patients treated with gonadotropins.

Intervention(s): A total of 195 patients underwent controlled ovarian stimulation (COS) with recombinant follicle stimulating hormone (rFSH) (50–150 IU/d). All patients were submitted upto three cycles of IUI.

Outcome: Primary outcome was the ability of AMH levels to predict clinical pregnancy at first attempt and the cumulative clinical pregnancy probability of upto three IUI cycles. Secondary outcomes were the relation of AMH, LH, FSH, BMI, age, parity and basic estradiol levels with each other and the outcome of IUI.

Results: The area under the receiver operating characteristic (ROC) curve in predicting clinical pregnancy for AMH at first attempt was 0.53 and for cumulative clinical pregnancy was 0.76. AMH levels were positively correlated with clinical pregnancy rate at first attempt and with cumulative clinical pregnancy rate, but negatively correlated with patient’s age and FSH levels. Patient’s FSH, LH levels were negatively correlated with cumulative clinical pregnancy rate.

Conclusions: AMH levels seem to have a positive correlation and patient’s age and LH levels had a negative correlation with the outcome of IUI and COS with gonadotropins. AMH concentration was significantly higher and LH was significantly lower in patients with a clinical pregnancy after three cycles of IUI treatment compared with those who did not achieve pregnancy.

Chinese abstract

目的：评估在应用促性腺激素治疗的患者的人抗苗勒管氏激素(AMH)水平是否与宫腔内人工授精结果有关。

处理方法：总计195名患者应用重组的卵泡刺激素（rFSH）（50-150 IU/d）进行促排卵（COS），所有患者进行3个IUI周期。

结局：第一个结果是AMH,水平能初步预测临床妊娠和3个IUI周期下累积临床妊娠概率。第二个结果是AMH, LH, FSH, BMI, 年龄，生育史和基础雌激素水平之间的相关性及与IUI结果的相关性。

结果：利用AHM作为初步预测临床妊娠的接受者操作特性曲线（ROC）下面积为0.53，预测积累临床妊娠面积为0.76。AMH水平与临床妊娠率初测及累计临床妊娠率正相关，而与患者年龄及FSH水平负相关。患者的FSH,LH水平与临床妊娠率相关。结论：AMH水平似乎与IUI及应用促性腺激素促排卵的结局成正相关，患者年龄及LH水平则与之呈负相关。经过3个周期IUI治疗的临床妊娠患者比未妊娠患者，AMH浓度显著高，LH显著低。

• Assisted reproductive technology
• estrogens
• infertility

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Corrigendum

Declaration of interest

The material contained in this article has not been published or submitted for publication elsewhere. All the authors contributed significantly and are in agreement with the content of the article. The authors report no conflicts of interest.