Evaluation of circulating betatrophin levels in gestational diabetes mellitus

Abstract

Experimental data indicate that betatrophin plays a significant role in the regulation of lipid metabolism and glucose homeostasis. In recent years, considerable attention has focused on the relationship between betatrophin and diabetes mellitus in humans. This case-control study included 45 women diagnosed with gestational diabetes mellitus (GDM) and 45 pregnant healthy controls. The groups were matched for maternal and gestational age and body mass index. Serum betatrophin levels were significantly higher in women with GDM (median = 635.8 ng/L; range: 290–1841.6 ng/L) compared to control subjects (median = 320.1 ng/L; range: 94.6–936.8 ng/L; p = 0.001). No significant correlations were observed between serum betatrophin levels and clinical or biochemical parameters in the control group. However, in the GDM group, serum betatrophin levels were positively correlated with weight gain during pregnancy (r = 0.304, p = 0.042), systolic blood pressure (r = 0.394, p = 0.007), fasting insulin level (r = 0.348, p = 0.019), and homeostatic model assessment insulin resistance (HOMA-IR; r = 0.311, p = 0.038). Multivariate stepwise linear regression analysis revealed that fasting insulin levels (β = 0.342, p = 0.022) and HOMA-IR (β = 0.312, p = 0.037) were independently associated with serum betatrophin levels.

Chinese abstract

实验数据表明，促胰岛生成素在脂质的代谢及糖类的稳态的调节方面起很重要的作用。近年来大量的注意力集中在促胰岛生成素和人类糖尿病的关系上。本病例对照研究包括45例诊断为妊娠期糖尿病的孕妇，以45例健康的孕妇作为对照组。以孕妇、胎龄、体重指数作为匹配项目。妊娠期糖尿病组(中位数=635.8ng/L；范围: 290–1841.6 ng/L)的血清促胰岛生成素水平显著高于对照组(中位数=320.1 ng/L；范围: 94.6–936.8 ng/L; p=0.001)。对照组的血清促胰岛生成素水平和临床、生物化学参数并没有发现有明显相关性。然而，妊娠期糖尿病组血清促胰岛生成素水平和妊娠期间体重增长(r=0.304, p=0.042)、收缩压(r=0.394, p=0.007)、空腹血糖(r=0.348, p=0.019)、与胰岛素抵抗相关的稳态模型(HOMA-IR;r=0.311, p=0.038)均有明显相关性。多元线性回归分析显示空腹血糖(β=0.342, p=0.022)及HOMA-IR (β =0.312, p=0.037)均与血清促胰岛生成素水平有独立相关性。

• Betatrophin
• gestational diabetes mellitus
• insulin resistance

Declaration of interest

The authors report no declarations of interest.