Examination of angiopoietin-like protein 4, neuropeptide Y, omentin-1 levels of obese and non-obese patients with polycystic ovary syndrome

Abstract

The pathogenesis of polycystic ovary syndrome (PCOS) and obesity is not clarified yet. But some parameters such as neuropeptide Y (NPY), angiopoietin-like protein (Angptl-4), omentin-1 are thought to be involved in this pathogenesis. In this study, we aimed to show possible effects of NPY, Angptl-4, omentin-1 throughout clinical parameters and hormones. Patients were divided into three groups. Group I; healthy volunteers, Group II; non-obese women with PCOS and group III; obese women with PCOS. Serum NPY, Angptl-4, free testosterone, total testosterone, luteinize hormone, sex hormone binding globulin, estradiol, dehydroepiandrosterone sulfate, androstenedione, triglycerides and low density lipoprotein cholesterol levels and HOMA-IR, Ferriman–Galwey scores were significantly higher in group II when compared with group I and similarly in group III when compared with group II (p < 0.005). While comparing all PCOS patients (obese + non-obese) with healthy volunteers, omentin-1 and high density lipoprotein cholesterol levels were significantly low in PCOS group (p < 0.005). As a result of this study, both in the obese and non-obese PCOS patients, there was a significant increase in levels of NPY and Angptl-4 and a significant decline in omentin-1 when compared to healthy subjects. In conclusion, insulin resistance in PCOS patients may be related to the differences of NPY, Angptl-4 and omentin-1 levels and the effects of these differences on metabolic pathways.

Chinese abstract

多囊卵巢综合征（PCOS）和肥胖的发病机制目前尚不明确。但认为一些参数如神经肽Y（NPY），血管生成素样蛋白（angptl-4），网膜素-1与其发病机制有关。在这项研究中，我们的目的是通过临床参数和激素的测量发现NPY、angptl-4及网膜素-1的可能作用。患者被分为III组：第I组为健康志愿者，第II组为非肥胖的PCOS患者，第III组为肥胖的PCOS患者。血清NPY、angptl-4、游离睾酮、总睾酮、黄体生成素、睾酮、性激素结合球蛋白、雌二醇、硫酸脱氢表雄酮、雄烯二酮、甘油三酯和低密度脂蛋白胆固醇水平、HOMA-IR及菲尔曼–高尔韦评分第II组均显著高于第I组，第III组与第II组比较时结果相似（p<0.005）。比较所有PCOS患者（肥胖和非肥胖）与健康志愿者，PCOS患者网膜素-1和高密度脂蛋白胆固醇水平均明显降低（P＜0.005）。这项研究的结果表明：肥胖及非肥胖的PCOS患者与健康受试者比较，NPY和angptl-4的水平均显著升高，网膜素-1的水平均明显降低。总之，PCOS患者胰岛素抵抗可能与NPY、angptl-4和网膜素-1水平的差异及这些差异对代谢途径的影响有关。

• Angptl-4
• NPY
• obesity
• omentin-1
• polycystic ovary syndrome

Declaration of interest

The authors declare no conflicts of interests. The authors alone are responsible for the content and writing of this article.