Association between serum adropin levels and gestational diabetes mellitus; a case–control study

Abstract

Gestational diabetes mellitus (GDM) is increasing worldwide. The aim of this study was to investigate the association between serum adropin concentration and GDM. In a case–control study, conducted in 2013, 40 pregnant women with GDM and 40 healthy pregnant women (controls) were evaluated. Fasting serum adropin and lipid concentration were measured during 24th–28th weeks of gestation for both groups. These factors were compared between the two groups using independent sample t-test. There was a significant difference in adropin levels between the two groups and mean adropin levels were lower in GDM group (p: 0.016). There was no significant correlation between serum adropin levels and body mass index as well as fasting blood glucose (FBS) or serum lipid profile including high-density lipoprotein, low-density lipoprotein, cholesterol and triglyceride concentration (p > 0.05). There was a significant association between adropin concentration and GDM even after using regression model for removing confounding factors (odds ratio = 0.681). Low serum adropin concentration is associated with GDM in Iranian pregnant women.

Chinese abstract

妊娠期糖尿病(GDM)是在世界范围内不断增长的疾病。研究的目的在于探究血清adropin水平与GDM之间的关系。在一项2013年进行的病例对照研究中纳入了40名患有GDM的妊娠期妇女和40名妊娠期健康女性（对照），妊娠24-28周时检测两组妇女的空腹血清adropin水平和血脂浓度。组间指标用独立样本t检验进行比较。两组adropin浓度出现显著差异，其中GDM组adropin蛋白平均水平较低(p: 0.016)。血清adropin水平与体质指数、空腹血糖(FBS)及包括高密度脂蛋白、低密度脂蛋白胆固醇和甘油三酯在内的血脂谱并无明显相关性(p>0.05).。即使是在使用回归模型去除混淆因素之后，血清adropin浓度与DGM仍呈现出明显的相关性(比值比=0.681)。伊朗妊娠妇女血清adropin浓度低与DGM相关。

Keywords:

• Adropin
• gestational diabetes mellitus
• metabolic disorders
• pregnancy

Declaration of interest

The authors have no conflict of interest to declare.