First case successful twin pregnancy by transdermal therapy for patients with 5.0 mm thick endometrium during frozen-thawed embryo transfer: a case report

Abstract

We reported the first case of thin endometrium patient with twin conceived via transdermal therapy during frozen-thawed embryo transfer (FET). The patient used Progynova administration to preparate endometrium in the first FET cycle. The endometrial thickness was 5.0 mm after 10 days of Progynova administration, the cycle was cancelled. In the second FET cycle, the transdermal therapy was used to support the endometrial development. The endometrial thickness reached 7.6 mm, two embryos were transferred on the day 4 of progesterone intramuscularly. The patient was carrying twins for nine months. There is a speculation that transdermal therapy may be effective for patients with thin endometrium during FET and provide a new method of clinical treatment.

Chinese abstract

我们报告了第一例子宫内膜薄的双胞胎妊娠患者，通过在冻融胚胎移植中的经皮治疗。患者在第一个FET周期应用补佳乐进行内膜准备。经过10天补佳乐的应用内膜厚度为5.0mm,周期取消。在第二个FET周期中，应用经皮治疗支持内膜生长。内膜厚度到达7.6mm,在应用黄体酮肌肉注射第4天移植了2个胚胎。患者怀了双胞胎到9个月。推测经皮治疗可能对子宫内膜薄的患者的FET周期有效，这提供一个临床治疗的新方法。

Keywords:

• Case report
• frozen-thawed embryo transfer
• thin endometrium
• transdermal therapy