Selenoprotein P is not elevated in gestational diabetes mellitus

Abstract

Selenoprotein P concentrations have been found to be associated with insulin resistance and elevated in patients with type 2 diabetes mellitus (DM). The aim of the present study was to investigate circulating selenoprotein P level and its possible relationship with metabolic parameters in gestational diabetes mellitus (GDM). Plasma selenoprotein P concentrations were measured in 30 pregnant women with GDM, 35 pregnant women without GDM and 22 healthy nonpregnant women. No difference in selenoprotein P levels was observed among the groups [6.2 (4.5–8.2), 7.9 (4.5–10.7) and 6.7 (5.3–9.1) ng/ml, respectively, p = 0.69]. In pregnant women with and without GDM, selenoprotein P did not correlate with age, gestational age, prepregnancy body mass index (BMI), HbA1c, glucose concentrations at oral glucose tolerance test (OGTT), area under curve (AUC) glucose, total cholesterol, LDL cholesterol and triglycerides levels (p > 0.05). But, there were statistically significant correlations between selenoprotein P and current BMI (r = −0.28, p = 0.04) and HDL cholesterol levels (r = 0.43, p = 0.01). We found that selenoprotein P concentrations are not elevated in women with GDM but associated with BMI and HDL cholesterol.

Chinese abstract

既往研究发现硒蛋白P浓度与2型糖尿病（DM）患者胰岛素抵抗及升高有关。本实验旨在评估循环中硒蛋白P水平，以及它与妊娠期糖尿病（GDM）患者代谢指标之间的关系。在30例妊娠期糖尿病妊娠女性、35例非妊娠期糖尿病妊娠女性、22例非妊娠女性中，我们测定了血清硒蛋白P水平。结果并没有发现硒蛋白P水平含量间存在差异[分别为6.2 (4.5–8.2), 7.9 (4.5–10.7)及6.7 (5.3–9.1) ng/ml,, p=0.69]。合并/不合并妊娠期糖尿病的妊娠女性，硒蛋白P水平与年龄、妊娠时年龄、孕前体重指数（BMI），HbA1c，口服葡萄糖耐量试验（OGTT）时的葡萄糖浓度，血糖曲线下面积（AUC），总胆固醇，LDL胆固醇和甘油三酯水平没有相关性（p>0.05）。然而，硒蛋白P水平和目前BMI之间存在明显相关性（r =—0.28, p =0.04），与HDL胆固醇水平也明显相关（r =0.43, p =0.01）。我们发现硒蛋白P浓度在GDM女性中没有升高，但是与BMI和HDL胆固醇却有相关性。

• BMI
• gestational diabetes mellitus
• glucose
• HDL cholesterol
• lipids
• selenoprotein P