The effect of medical versus surgical treatment of spontaneous miscarriage on subsequent in vitro fertilization cycles

Abstract

Objective: To evaluate the effect of dilation and curettage (D&C) and misoprostol as treatments for spontaneous miscarriage (SM) on in vitro fertilization (IVF) parameters in the subsequent IVF cycle.

Design: Multicenter, retrospective, cohort study. Women treated for SM after IVF treatment with D&C or misoprostol and underwent a subsequent IVF cycle was included. The main outcome measures were ovarian response, endometrial thickness and pregnancy rate in the subsequent IVF cycle after MA.

Results: Among 73 patients with miscarriage, 41 had D&C and 32 were given misoprostol. Baseline serum follicle stimulating hormone (FSH) levels and ovarian responses before and after treatment of miscarriage were comparable. No significant differences were observed between the D&C and the misoprostol groups in basal FSH levels, endometrial thickness and parameters of ovarian response in the subsequent IVF cycle.

Conclusion: D&C and misoprostol are both effective treatments for IVF patients with miscarriage, without an adverse effect on subsequent IVF treatment outcome.

Chinese abstract

目的：评估刮宫术(D&C)和米索前列醇治疗自然流产(SM)对随后体外受精（IVF）周期IVF参数的影响。

实验设计：多中心回顾性队列研究。IVF后接受D&C或米索前列醇治疗SM并于之后进行IVF的妇女被纳入了此项研究。主要观察指标为MA后IVF周期中的卵巢反应性，子宫内膜厚度和妊娠率。

结果：流产的73名妇女中，41名接受D&C，32名接受米索前列醇处理。比较处理流产前后基础血清卵泡刺激素(FSH)水平和卵巢反应性。并未发现D&C组和米索前列醇组在基础FSH水平，内膜厚度和随后IVF周期的卵巢反应性上有显著差异。

结论： D&C和米索前列醇均为治疗伴流产IVF患者的有效手段，且对随后IVF的治疗效果不产生任何副作用。

• D&C
• IVF
• lag period
• miscarriage
• misoprostol

Declaration of interest

The authors declare no conflicts of interest. The authors alone are responsible for the content and writing of this article.