An evaluation of homocysteine, C-reactive protein, lipid levels, neutrophils to lymphocyte ratio in postmenopausal osteopenic women

Abstract

Objective: In the present study, the risk coefficients of serum homocysteine (hcy), lipid levels, C-reactive protein (CRP), neutrophils to lymphocyte ratio (NLR) in postmenopausal osteopenic women were determined.

Methods: We enrolled 269 patients with postmenopausal women from Hangzhou No.1 Hospital gynecological clinic, who aged 45 to 60 years old and never received menopause hormone therapy. According to the bone mineral density determination results, subjects were divided into normal group (n  =  128), osteopenia group (n  =  141). Bone mineral density (BMD) was measured by dual-energy X-ray absorptiometry (DXA). Serum hcy, CRP and lipid indexes were determined by enzyme chemiluminescence immunoassay.

Results: The odds ratios (OR) and 95% confidence intervals (CI) of those variables (menopausal age, duration of menopause, LDL, CRP, hcy and NLR) were found significant (p  <  0.05). Menopausal age, duration of menopause, LDL, CRP, hcy and NLR variables were found statistically significant in the analysis of receiver operating characteristic (ROCs).

Conclusion: The present study shows that menopause age, duration of menopause, serum LDL, CRP, hcy and NLR levels are risk factors for postmenopausal osteopenic women, which may be used as the indicators of bone loss in postmenopausal women.

Chinese abstract

目的：此研究，测定绝经后骨量减少妇女血清中的的风险系数血清同型半胱氨酸（hcy）、血脂水平,C反应蛋白（CRP）,中性粒细胞在淋巴细胞中的比率。

方法：在杭州第一医院妇科门诊招募了269名绝经后的妇女，年龄从45-60岁，没有进行过任何的激素治疗。根据骨密度的测量结果，将研究对象划分为正常组（128人），骨量减少组（141人）。骨密度（BMD）是通过双能x线骨密度测量仪（DXA）测定。血清同型半胱氨酸、c反应蛋白、血脂水平是通过酶化学发光免疫测量技术测定的。

结果：这些变量（绝经年龄，绝经持续时间，LDL，CRP，同型半胱氨酸和NLR）的比值比（OR）及95%的置信区间都是有意义的（p<0.05）。这些变量（绝经年龄，绝经持续时间，LDL，CRP，同型半胱氨酸和NLR）的变化在ROC曲线上也是有统计学意义的。

结论：绝经年龄，绝经持续时间，血清LDL，CRP，同型半胱氨酸和NLR的水平是绝经后妇女骨量减少的危险因素，这些因素可以用来作为绝经后妇女骨量减少的指标。

• C-reactive protein
• homocysteine
• lipid
• neutrophils to lymphocyte ratio
• osteopenia
• postmenopausal

Declaration of interest

The authors report no conflicts of interest. The study was supported by MENOPAUSE project from National health and family planning commission scientific research funds (WKJ-2013–2-024), Hangzhou medical science and technology projects (2011Z003), Hangzhou science and technology development projects (20120533Q04).

Supplementary information available online