Cystatin C, a novel cardiometabolic risk marker in women with polycystic ovary syndrome

Abstract

Objective: To investigate the impact of urinary albumin excretion (UAE) and cystatin C on the metabolic components of polycystic ovary syndrome (PCOS).

Methods: Seventy-five women with PCOS were divided into two groups according to metabolic syndrome as MetS + and MetS−. Clinical, metabolic and renal parameters were compared between the groups. Correlation analyses were performed between cystatin C, microalbuminuria and clinical and metabolic parameters in women with PCOS.

Results: Waist/hip ratio (WHR), body mass index, LDL cholesterol, triglyceride, total cholesterol, cystatin C, UAE were significantly higher in the MetS + group compared with the MetS − one. HDL cholesterol was significantly higher in the MetS − group than the MetS + one. The UAE positively correlates with LDL cholesterol, triglyceride and total cholesterol levels. Cystatin C positively correlates with UAE, WHR, LDL cholesterol, triglyceride, total cholesterol levels.

Conclusions: Evaluating UAE and cystatin C may be important for the detection of target subjects at high risk for future metabolic syndrome and cardiovascular disease.

Chinese abstract

目的：调查尿白蛋白排泄（UAE）和胱抑素c对多囊卵巢综合征患者代谢的影响。

方法：75名多囊卵巢综合征患者依据代谢综合征分为MetS +和 MetS- 组.比较这两个组之间的临床表现，代谢和肾脏参数。分析其胱抑素c、尿微量白蛋白，临床症状和代谢参数之间的相关性。

结果： MetS + 组的腰臀比（WHR），BMI，LDL，甘油三酯，总胆固醇，胱抑素c，尿白蛋白排泄（UAE）明显高于MetS- 组，而 MetS-组的HDL明显高于MetS + 组。尿白蛋白排泄（UAE）与LDL，甘油三酯，总胆固醇呈明显正相关。胱抑素c与尿白蛋白排泄（UAE），腰臀比（WHR），LDL，甘油三酯，总胆固醇水平呈明显正相关。

结论：UAE和胱抑素C的评估可能对将来具有代谢综合征和心血管疾病高危的目标人群具有重要意义。

• Cystatin C
• metabolic syndrome
• microalbuminuria
• polycystic ovary syndrome
• urinary albumin excretion