Follicular fluid norepinephrine and dopamine concentrations are higher in polycystic ovary syndrome

Abstract

The aim of the present study was to compare follicular fluid (FF) levels of norepinephrine (NE) and dopamine (DA) in polycystic ovary syndrome (PCOS) and non-PCOS patients who underwent in vitro fertilization (IVF). Forty-seven PCOS patients (study group) and 61 patients with male factor infertility (control group) who underwent IVF using GnRH agonist protocol were recruited. Concentrations of NE and DA were measured in FF specimens of all patients. Demographic characteristics were comparable between the groups. Significantly higher levels of NE were measured in FF of PCOS patients (median: 61.05 nmol/l) compared to those with male infertility (median: 49.82 nmol/l). Similarly, significantly higher levels of DA were measured in FF of PCOS patients (median: 23.70 nmol/l) compared to those with male infertility (median: 18.28 nmol/l). In conclusion, the FF concentrations of both catecholamine are increased in PCOS patients when compared to non-PCOS patients.

Chinese abstract

本研究的目的是比较接受体外受精(IVF)的多囊卵巢综合征(PCOS)和非多囊卵巢综合征患者的卵泡液(FF)去甲肾上腺素(NE)和多巴胺(DA)水平。47例PCOS患者(研究组)和61例因男性因素不育的患者(对照组)，这两组患者都使用了促性腺激素释放激素激动剂方案进行IVF。测量所有患者卵泡液标本的NE、DA浓度。与男性不孕组(中位数:49.82 nmol / l)相比PCOS患者(中位数:61.05 nmol / l）的卵泡液中NE明显升高。同样，与男性不孕组(中位数:18.28 nmol / l)相比PCOS患者(中位数:23.70 nmol / l）的卵泡液中DA也明显升高。结论，PCOS患者卵泡液儿茶酚胺的浓度明显高于非PCOS患者。

• Catecholamine
• dopamine
• in vitro fertilization
• norepinephrine
• polycystic ovary syndrome