The effect of vitamin D on primary dysmenorrhea with vitamin D deficiency: a randomized double-blind controlled clinical trial

Abstract

Dysmenorrhea is common among women of reproductive age. This study aim was to investigate the effect of vitamin D (vit D) supplementation in treatment of primary dysmenorrhea with vit D deficiency. A randomized double-blind placebo-controlled clinical trial was conducted on 60 women with primary dysmenorrhea and vit D deficiency referred to our clinic at Arash Women’s Hospital from September 2013 to December 2014. Eligible women were randomly assigned into treatment and control groups (30 in each group). Individuals in the treatment group received 50 000 IU oral vit D and the control group received placebo weekly for eight weeks. After two months of treatment, there was a significant difference in serum vit D concentration between the two groups (p < 0.001). Pain severity decreased significantly in treatment group after eight weeks of treatment. There was a significant difference in pain intensity between the two groups after eight weeks of treatment and one month after the end of treatment (p < 0.001 for both). A weekly high dose (50 000 IU) oral vit D supplementation for eight weeks in patients with primary dysmenorrhea and vit D deficiency could improve pain intensity.

Chinese abstract

痛经在育龄期女性中普遍存在。本研究的目的在于评估补充维生素D（vit D）对伴随vitD缺乏的原发性痛经的治疗作用。2013年9月至2014年12月，在Arash妇产医院门诊对60名伴随维生素D缺乏的原发性痛经患者进行了一项随机、双盲的安慰剂对照临床试验。符合纳入条件的女性被随机分配到治疗组与对照组（每组30例）。治疗组女性每周口服50000IU vit D，对照组女性每周口服安慰剂，共服用8周。两个月后，两组患者的血清vit D浓度有显著差异（p < 0.001）。八周的治疗后，治疗组女性的疼痛严重程度显著降低。两组间女性的疼痛强度在8周治疗后以及治疗结束1个月后有明显差异（两者p < 0.001）。因此，对于缺乏vit D的原发性痛经患者，每周补充口服vit D（50000 IU），服用8周可有效缓解疼痛强度。

• Dysmenorrhea
• supplementation
• vitamin D

Declaration of interest

The authors have no conflict of interest to report.