Short versus long gonadotropin-releasing hormone analogue suppression protocols in advanced age women undergoing IVF/ICSI

Abstract

Objective: To compare the effective of two GnRH-a protocols for ovarian stimulation in advanced age women undergoing IVF/ICSI cycles.

Study design: A total of 1149 IVF-ET/ICSI cycles were retrospectively identified. The cycles were divided two groups, namely a long-protocol group and a short-protocol group.

Results: The numbers of oocytes retrieved, and high-quality embryos in the long-protocol group were significantly greater than those in the short-protocol group. In the long-protocol group, the implantation and pregnancy rates were 17.22% and 33.67%, respectively, and these values were significantly higher than those in the short-protocol group (8.24% and 15.96%, p < 0.05).

Conclusions: Our study demonstrated that the long protocol was superior to the short protocol for advanced age women.

Chinese abstract

目的: 比较IVF/ICSI高龄妇女使用两种促性腺激素释放激素类似物抑制方案对卵巢刺激的效果。

研究设计: 回顾性分析1149个IVF-ET/ICSI周期。这些周期被分成两组, 一个长方案组和一个短方案组。

结果: 在长方案组募集到卵母细胞的数量和高质量的胚胎数量显著大于短方案组。在长方案组, 植入率和妊娠率分别为17.22%和33.67%, 这些均显著高于短方案组(8.24% 和 15.96%, p < 0.05)。

结论: 我们的研究表明对高龄妇女给长方案的促性腺激素释放激素类似物治疗优于短方案。

• GnRH analogue
• long protocol
• short protocol

Acknowledgements

We acknowledge the help of the staff and patients of the Centre for Reproductive Medicine in the First Affiliated Hospital of Sun Yat-sen University.

Declaration of interest

The authors report no conflicts of interest.