Lack of predictive value of HbA₁ for impaired glucose tolerance in polycystic ovary syndrome

I. M. Golland Department of Obstetrics, Endocrinology and Medical Statistics, University Hospital of South Manchester, Manchester, UK; Department of Gynaecology, Endocrinology and Medical Statistics, University Hospital of South Manchester, Manchester, UK

C. A. Vaughan Williams Department of Obstetrics, Endocrinology and Medical Statistics, University Hospital of South Manchester, Manchester, UK; Department of Gynaecology, Endocrinology and Medical Statistics, University Hospital of South Manchester, Manchester, UK

S. M. Shalet Department of Obstetrics, Endocrinology and Medical Statistics, University Hospital of South Manchester, Manchester, UK; Department of Gynaecology, Endocrinology and Medical Statistics, University Hospital of South Manchester, Manchester, UK

L. H. Million Department of Obstetrics, Endocrinology and Medical Statistics, University Hospital of South Manchester, Manchester, UK; Department of Gynaecology, Endocrinology and Medical Statistics, University Hospital of South Manchester, Manchester, UK

M. Elstein Department of Obstetrics, Endocrinology and Medical Statistics, University Hospital of South Manchester, Manchester, UK; Department of Gynaecology, Endocrinology and Medical Statistics, University Hospital of South Manchester, Manchester, UK

Abstract

Twenty-seven women with polycystic ovary syndrome (PCO) and 17 control women had a 75 g oral glucose tolerance test (oGTT) performed. Although glucose tolerance was impaired in the obese (body mass index < 25 kg/m²) women with PCO, glycosylated hemoglobin (HbA₁) concentrations did not exceed the normal upper limit (7.2%). In all 44 women, there was no correlation between HbA₁ and fasting glucose (r = 0.082, p = 0.63) but there was a significant correlation between HbA₁ and summed glucose levels through the oGTT (r = 0.389, p = 0.02). HbA₁ measurement does not predict the presence of impaired glucose tolerance in women with PCO.

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Lack of predictive value of HbA₁ for impaired glucose tolerance in polycystic ovary syndrome

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Lack of predictive value of HbA1 for impaired glucose tolerance in polycystic ovary syndrome

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Lack of predictive value of HbA₁ for impaired glucose tolerance in polycystic ovary syndrome