Impact of different gonadotropin and GnRH agonist regimens on serum and follicular fluid hormone levels and folliculogenesis

M. Filicori Reproductive Endocrinology Center, Department of Obstetrics and Gynecology, University of Bologna, Bologna, Italy

G. E. Cognigni Reproductive Endocrinology Center, Department of Obstetrics and Gynecology, University of Bologna, Bologna, Italy

A. Falbo Reproductive Endocrinology Center, Department of Obstetrics and Gynecology, University of Bologna, Bologna, Italy

R. Amone Reproductive Endocrinology Center, Department of Obstetrics and Gynecology, University of Bologna, Bologna, Italy

C. Pari Reproductive Endocrinology Center, Department of Obstetrics and Gynecology, University of Bologna, Bologna, Italy

W. Ciampaglia Reproductive Endocrinology Center, Department of Obstetrics and Gynecology, University of Bologna, Bologna, Italy

D. Spettoli Reproductive Endocrinology Center, Department of Obstetrics and Gynecology, University of Bologna, Bologna, Italy

P. Casadio Reproductive Endocrinology Center, Department of Obstetrics and Gynecology, University of Bologna, Bologna, Italy

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Abstract

Gonadotropin-releasing hormone agonists (GnRH-a) are currently used in virtually every assisted reproduction ovulation induction cycle to reduce cancellation rates and to improve treatment outcome. The combination of GnRH-a and gonadotropins appears to be safe and devoid of direct side-effects even when GnRH-a are administered in early pregnancy. We recently showed that long GnRH-a regimens are preferable to short (flare-up) regimens as they result in a greater follicle yield and a better intrafollicular endocrine environment. Thus, the combined use of long GnRH-a regimens and gonadotropins for assisted reproduction ovulation induction is destined to further grow.

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Impact of different gonadotropin and GnRH agonist regimens on serum and follicular fluid hormone levels and folliculogenesis

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Impact of different gonadotropin and GnRH agonist regimens on serum and follicular fluid hormone levels and folliculogenesis

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