Superovulation with urinary human follicle-stimulating hormone: correlations with body mass index and body fat distribution

F. Zullo Department of Gynecologic and Pediatric Sciences, Medical School of Catanzaro, University of Reggio Calabria Ospedale ‘A. Pugliese', Catanzaro;, Department of Gynecology and Obstetrics, University ‘Federico II’ of Napoli, Naples, Italy

C. Di Carlo Department of Gynecologic and Pediatric Sciences, Medical School of Catanzaro, University of Reggio Calabria Ospedale ‘A. Pugliese', Catanzaro;, Department of Gynecology and Obstetrics, University ‘Federico II’ of Napoli, Naples, Italy

M. Pellicano Department of Gynecologic and Pediatric Sciences, Medical School of Catanzaro, University of Reggio Calabria Ospedale ‘A. Pugliese', Catanzaro;, Department of Gynecology and Obstetrics, University ‘Federico II’ of Napoli, Naples, Italy

C. Catizone Department of Gynecologic and Pediatric Sciences, Medical School of Catanzaro, University of Reggio Calabria Ospedale ‘A. Pugliese', Catanzaro;, Department of Gynecology and Obstetrics, University ‘Federico II’ of Napoli, Naples, Italy

P. Mastrantonio Department of Gynecologic and Pediatric Sciences, Medical School of Catanzaro, University of Reggio Calabria Ospedale ‘A. Pugliese', Catanzaro;, Department of Gynecology and Obstetrics, University ‘Federico II’ of Napoli, Naples, Italy

C. Nappi Department of Gynecologic and Pediatric Sciences, Medical School of Catanzaro, University of Reggio Calabria Ospedale ‘A. Pugliese', Catanzaro;, Department of Gynecology and Obstetrics, University ‘Federico II’ of Napoli, Naples, Italy

Abstract

Our objective was to i nvestigate the relationship between body mass index (BMI), waist/hip ratio (WHR), follicle-stimulating hormone (FSH) dose, length of stimulation and clinical outcome in infertile women with and without polycystic ovary syndrome (PCOS) undergoing controlled ovarian hyper stimulation.

Controlled ovarian hyperstimulation was induced in 60 women for a total of 111 cycles (48% in PCOS patients) with urinary human FSH (u-hFSH).

A significant correlation between BMI, u-hFSH dose and duration of stimulation was found in PCOS and non-PCOS patients with WHR < 0.8. These correlations were not present in PCOS patients with WHR > 0.8. Pregnant patients received significantly less ampules ofu-hFSH.

From our data we suggest a controlled ovarian hyperstimulation protocol, for obese non-PCOS patients and obese PCOS patients with WHR < 0.8, starting with a double dose of u-FSH.

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Superovulation with urinary human follicle-stimulating hormone: correlations with body mass index and body fat distribution

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Superovulation with urinary human follicle-stimulating hormone: correlations with body mass index and body fat distribution

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