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Abstract
The calcium antagonistic effect of 17α-estradiol derivatives was investigated in vitro in human aortic smooth muscle cells. The substances tested were 14α-estradiol, 17α-ethinylestradiol, the scavestrogens J811 and J861, and 17β-estradiol. Examinations were carried out by measuring 45Ca influx into the cells. All compounds showed a significant inhibition of calcium influx at the concentration of 10−6 M. The strongest effect could be registered for the scavestrogens. Since these substances are virtually devoid of estrogenic actitivity, they may offer advantages over 17β-estradiol in the therapy and prevention of cardiovascular disease.
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Notes on contributors
T. H. Lippert
Joyce Laing works in the Department of Child and Family Psychiatry, Playfield House, Cupar, Fife, and is a Consultant Art Therapist to Psychiatric Hospitals and Prisons and Chairwoman of the Scottish Society of Art and Psychology.