CalDAG-GEFI and platelet activation

Abstract

Rapid activation of platelets at sites of vascular injury is a critical event in thrombosis and hemostasis. Here, we review recent findings, which (a) identified CalDAG-GEFI (RasGRP2) at the nexus of the rapid Ca²⁺-dependent platelet activation, (b) demonstrated a complex synergy between signaling provided by CalDAG-GEFI, protein kinase C and the Gi-coupled receptor for ADP, P2Y12, and (c) suggested CalDAG-GEFI as a novel target for anti-platelet therapy.

• CalDAG-GEFI
• RasGRP2
• calcium signaling
• P2Y12
• integrin activation
• thromboxane A₂
• thrombosis