The pharmacology of sunburn erythema

Abstract

The role of pharmacological substances produced by resident cells in the skin, particularly keratinocytes, mast cells and probably endothelial cells, on functional and cellular aspects of the sunburn response is now becoming more clear. Although new information on the role of adhesion molecules is exciting, the identity of UVsvoked soluble mediators which evoke expression of ELAM-1 and its corresponding neutrophil receptors is awaited, as is the identity of chemoattractants and activators of the immigrant cells. The relevance of these findings to inflammatory photodermatoses is also awaited.