The absorption of 8-methoxypsoralen from lipid-containing semisolid matrices for oral use: a study in humans

Abstract

The aim of the study was to compare the pharmacokinetics of two semisolid matrix formulations of 8-MOP with commercial capsules containing 8-MOP dissolved in a mixture of solvents. One of the semisolid matrices contained oil because of the absorption-enhancing effect of oil previously observed in rabbits. The plasma level of 8-MOP was measured using a high-performance liquid chromatography method. No significant differences between the area under the curve values and the peak plasma concentrations were found, demonstrating that the oil component in the matrix did not specifically influence the bioavailability of 8-MOP in humans. This result is in contrast with our previous study in rabbits.

Key Words:

• 8-Methoxypsoralen
• Semisolid matrix
• Lipid formulations