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Abstract
In addition to the importance of bioavailability to reliable therapy, the three leading tetracyclines used in the treatment of acne have dissimilar tissue distributions and lipophilic characteristics which may impart different antimicrobial efficacy. The purpose of this study was to compare the in vivo antimicrobial effects of minocycline, doxycycline and tetracycline. The results of this study confirm that normal dosages of minocycline hydrochloride capsules in fast-release powder form produced significanctly superior in vivo reductions in Propionibacterium acnes compared to that produced by normal dosages of doxycycline monohydrate and tetracycline hydrochloride. In addition, minocycline produced much greater residual antimicrobial activity than the other two drugs after the end of the treatment period.