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Abstract
We report a case of necrobiosis lipoidica diabeticorum in a 36-year-old man suffering from uncompensated diabetes mellitus. The dermatosis was characterized by dark-red infiltrated patches with protruding peripheral borders located on the lower extremities, the dorsal aspects of the feet and hands, and the trunk. Histologically the lesions showed a palisaded granuloma in the middermis. The patient was treated with oral cyclosporin A (CsA) which resulted in a marked improvement in the clinical picture. The rationale for this therapeutic approach is briefly discussed.