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Abstract
Toxic epidermal necrolysis (TEN) is the most severe type of cutaneous reactions to drugs. Involvement of the epithelium of the gastrointestinal and respiratory tracts contribute to the severity of the disease. Antibacterial sulphonamides, anticonvulsants, allopurinol, several antibiotics and some antiinflammatory agents including steroids are the drugs associated with the highest risks. Therapy of this self-limited disease relies on symptomatic management based on the same principles as for major burns.
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