Modification by S-Adenosyl-L-Homocysteine of Norepinephrine In-Vitro Uptake in Rat Brain Homogenates

P. Fonlupt Laboratory of Biological Chemistry INSERM Unit 205, National Institute of Applied Science at Lyon 20, Albert Einstein Avenue 69621 Villeurlaurne Cedex, Lyon, France

C. Rey Laboratory of Biological Chemistry INSERM Unit 205, National Institute of Applied Science at Lyon 20, Albert Einstein Avenue 69621 Villeurlaurne Cedex, Lyon, France

H. Pacheco Laboratory of Biological Chemistry INSERM Unit 205, National Institute of Applied Science at Lyon 20, Albert Einstein Avenue 69621 Villeurlaurne Cedex, Lyon, France

Abstract

After incubation of rat brain homogenates with S-adenosyl-L-homocysteine (10 μM), norepinephrine uptake was modified according to the norepinephrine concentration. For low-range concentrations, uptake was lowered, whereas for high-range concentrations, uptake was increased.

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Modification by S-Adenosyl-L-Homocysteine of Norepinephrine In-Vitro Uptake in Rat Brain Homogenates

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Modification by S-Adenosyl-L-Homocysteine of Norepinephrine In-Vitro Uptake in Rat Brain Homogenates

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