Assignment of the human serotonin 4 receptor gene (HTR4) to the long arm of chromosome 5 (5q31–q33)

Sven Cichon Institute of Human Genetics, University of Bonn, Wilhelmstr. 31, 53111, Bonn, Germany

Kristina Kesper Institute of Human Genetics, University of Bonn, Wilhelmstr. 31, 53111, Bonn, Germany

Peter Propping Institute of Human Genetics, University of Bonn, Wilhelmstr. 31, 53111, Bonn, Germany

Markus M. Nöthen Institute of Human Genetics, University of Bonn, Wilhelmstr. 31, 53111, Bonn, Germany

Abstract

In the present study, we report the chromosomal localization of the human 5-HT₄ receptor gene (HTR4) by the analysis of somatic cell hybrids. Based upon genomic sequences of the HTR4 gene, a primer set was selected that reacted with human genomic DNA but not mouse or hamster genomic DNA. Using monochromo-soma1 hybrid cell lines of the NIGMS Mapping Panel 2 we localized the HTR4 gene to human chromosome 5. To confirm the localization on chromosome 5 and to further sublocalize the HTR4 gene, the radiation hybrid panel RH3 was similarly analysed. Significant linkage was obtained to genetic marker D5S2654. This localizes the HTR4 gene to human chromosome 5q31-q33.

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Assignment of the human serotonin 4 receptor gene (HTR4) to the long arm of chromosome 5 (5q31–q33)

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Assignment of the human serotonin 4 receptor gene (HTR4) to the long arm of chromosome 5 (5q31–q33)

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