Selective synthesis of panthenyl esters by a kinetically controlled enzymatic process

Abstract

Panthenyl esters (panthenyl monoacetate and panthenyl diacetate) were synthesized in high yields (≈100%) by a kinetic reaction control using a commercial immobilized Candida Antarctica lipase B (Novozyme 435) in acetonitrile. The enzyme showed excellent synthetic activity, regioselectivity, and operational stability under the conditions used.

Keywords::

• Panthenyl esters
• lipase
• transesterification

Declaration of interest: The authors report no declarations of interest. The authors alone are responsible for the content and writing of the paper.

Electronic supplementary material: The online version of this article contains supplementary material, which is available to authorized users. Spectra by nuclear magnetic resonance (NMR) of panthenyl esters are produced.