Continuous Synthesis of (R)-(+)-Benzaldehydecyanohydrin Using (R)-Oxynitrilase in Lyotropic Liquid Crystals

Peter Miethe Institute of Biotechnology, Martin-Luther-University, Weinbergweg, 16a 0-4050, Halle, Germany

Ingeborg Jansen Institute of Enzyme Technology, Heinrich-Heine-University, Düsseldorf, P.O. Box 2050, W-5170, Jülich, Germany

Uwe Niedermeyer Institute of Enzyme Technology, Heinrich-Heine-University, Düsseldorf, P.O. Box 2050, W-5170, Jülich, Germany

Udo Kragl Institute of Biotechnology, Research CenterJülich, P.O. Box 1913, W-5170, Jülich, Germany

Regine Haftendorn Institute of Biotechnology, Martin-Luther-University, Weinbergweg, 16a 0-4050, Halle, Germany

Maria-Regina Kula Institute of Enzyme Technology, Heinrich-Heine-University, Düsseldorf, P.O. Box 2050, W-5170, Jülich, Germany

Christian Wandrey Institute of Biotechnology, Research CenterJülich, P.O. Box 1913, W-5170, Jülich, Germany

Karl-Heinz Mohr Institute of Biotechnology, Martin-Luther-University, Weinbergweg, 16a 0-4050, Halle, Germany

Helmut-Walter Meyer Department of Electronmicroscopy, Medical Faculty, Friedrich-Schiller-University, Jaen, Ziegelmühlenweg 1, 0-6900, Jena, Germany

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Abstract

The possibility of using the enzyme (R)-Oxynitrilase in a biphasic lyotropic liquid crystal/dibutylether system has been demonstrated. This reaction system is applicable for the continuous production of (R)-benzaldehydecyanohydrin in a fixed bed reactor. The optical purity was between 94 and 96% ee and independent of the flow rate. The space time yield was maximal (2650 g/(1*d)) at a flow rate of 1.6 ml/min.

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Continuous Synthesis of (R)-(+)-Benzaldehydecyanohydrin Using (R)-Oxynitrilase in Lyotropic Liquid Crystals

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Continuous Synthesis of (R)-(+)-Benzaldehydecyanohydrin Using (R)-Oxynitrilase in Lyotropic Liquid Crystals

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