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DNA Sequence Volume 12, 2001 - Issue 5-6
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Original Article

Cloning of the Proto-oncogene c-src from Rat Testis

Otor Al-Khalilt Department of Physiology, Center for Cell and Molecular Signaling, Emory University School of Medicine, Atlanta, GA, USA
,
B. J. Duke Department of Physiology, Center for Cell and Molecular Signaling, Emory University School of Medicine, Atlanta, GA, USA
,
Shawn Zeltwanger Department of Physiology, Center for Cell and Molecular Signaling, Emory University School of Medicine, Atlanta, GA, USA
,
Douglas C. Eaton Department of Physiology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX, USA
,
Bret Spier Department of Physiology, Center for Cell and Molecular Signaling, Emory University School of Medicine, Atlanta, GA, USA
&
James D. Stockand Department of Physiology, Center for Cell and Molecular Signaling, Emory University School of Medicine, Atlanta, GA, USACorrespondence[email protected]
Pages 425-429 | Received 09 Jan 2001, Published online: 11 Jul 2009
 
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Abstract

The cellular homolog of the oncogene v-src, the proto-oncogene c-src, was cloned from rat testis using a high stringency polymerase chain reaction. Rat c-src cDNA shared identity with chicken and mouse, and Rous sarcoma virus c-src and v-src, respectively. Rat c-Src protein was 98% homologous to both human and mouse c-Src. Interestingly, rat Src contained one extra amino acid compared to the mouse protein. As expected, the rat testis Src lacked the six extra residues common to the neuronal Src identified in human and mouse. Reporting of the cDNA sequence for non-neuronal, rat c-src should facilitate experimentation into cell growth and transformation using rat tissues as models of human disease.

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