The rat thymidine kinase gene 5′ region: evolution of a promoter

Santosh S. Arcot Department of Biochemistry and Molecular Biology, Louisiana State University Medical Center, New Orleans, LA, 70112, USA; Department of Molecular Genetics, Alton Ochsner Medical Foundation, 1516 Jefferson Highway, New Orleans, LA, 70112, USA

Vicki L. Traina-Dorge Department of Biochemistry and Molecular Biology, Louisiana State University Medical Center, New Orleans, LA, 70112, USA; Department of Molecular Genetics, Alton Ochsner Medical Foundation, 1516 Jefferson Highway, New Orleans, LA, 70112, USA

Prescott L. Deininger Department of Biochemistry and Molecular Biology, Louisiana State University Medical Center, New Orleans, LA, 70112, USA; Department of Molecular Genetics, Alton Ochsner Medical Foundation, 1516 Jefferson Highway, New Orleans, LA, 70112, USA

Abstract

The nucleotide sequence of the rat thymidine kinase (tk) gene 5′ region was determined and compared to the 5′ sequences of the tk gene from mouse, human, hamster and chicken. This analysis revealed the highest degree of homology to be between the rat and the mouse sequences and correspondingly greater sequence variation relative to the other species. There has apparently been an especially high rate of change in regions that have been demonstrated to be protein binding regions in some of these promoters. This has led to changes in the potential transcription factors bound by some of these promoters.

Key Words:

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

The rat thymidine kinase gene 5′ region: evolution of a promoter

Information for

Open access

Opportunities

Help and information

The rat thymidine kinase gene 5′ region: evolution of a promoter

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature