Nucleotide sequence of bovine interleukin-6 cDNA

L. Droogmans Laboratoire de Chimie Biologique, Universite Libre de Bruxelles, 67, Rue des Chevaux, 1640 Rhode-St-Genese, Belgium, (+32) 2 650 9826, (+32) 2 650 9999

I. Cludts Laboratoire de Chimie Biologique, Universite Libre de Bruxelles, 67, Rue des Chevaux, 1640 Rhode-St-Genese, Belgium, (+32) 2 650 9826, (+32) 2 650 9999

Y. Cleuter Laboratoire de Chimie Biologique, Universite Libre de Bruxelles, 67, Rue des Chevaux, 1640 Rhode-St-Genese, Belgium, (+32) 2 650 9826, (+32) 2 650 9999

R. Kettmann Facultes Agronomiques de Cembloux, UER Biologie Moleculaire, 13, Avenue Marechal Juin, 5030, Gembloux, Belgium

A. Burny Laboratoire de Chimie Biologique, Universite Libre de Bruxelles, 67, Rue des Chevaux, 1640 Rhode-St-Genese, Belgium, (+32) 2 650 9826, (+32) 2 650 9999; Facultes Agronomiques de Cembloux, UER Biologie Moleculaire, 13, Avenue Marechal Juin, 5030, Gembloux, Belgium

Abstract

We report the cloning of bovine interleukin-6 (IL-6) cDNA. The clone was isolated from a bovine-leukemia virus (BLV)-induced B cell-lymphosarcoma cDNA library cloned in the bacteriophage lambda gt11. The cDNA encodes a full length IL-6 protein made of 208 amino acids with 65, 53, 42 and 42% homology to published sequences of porcine, human, mouse and rat IL-6, respectively. The significance of IL-6 expression in a BLV-induced tumor is briefly discussed.

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Nucleotide sequence of bovine interleukin-6 cDNA

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Nucleotide sequence of bovine interleukin-6 cDNA

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