Nucleotide sequence of a cDNA encoding the chicken receptor protein kinase of the TGF-β receptor family

Tsutomu Nohno Department of Pharmacology, Kawasaki Medical School, 577 Matsushima, Kurashiki City, 701-01, Japan

Shoji Sumitomo Department of Pharmacology, Kawasaki Medical School, 577 Matsushima, Kurashiki City, 701-01, Japan

Tetsuya Ishikawa Department of Biochemistry, Kawasaki Medical School, 577 Matsushima, Kurashiki City, 701-01, Japan

Chiyo Ando Department of Internal Medicine, Kawasaki Medical School, 577 Matsushima, Kurashiki City, 701-01, Japan

Seikoh Nishida Department of Internal Medicine, Kawasaki Medical School, 577 Matsushima, Kurashiki City, 701-01, Japan

Sumihare Noji Department of Biological Science and Technology, Faculty of Engineering, University of Tokushima, 2-1 Minami-Josanjima, Tokushima City, 770, Japan

Taiichi Saito Department of Pharmacology, Kawasaki Medical School, 577 Matsushima, Kurashiki City, 701-01, Japan

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Abstract

We have isolated RPK-2 cDNA from chick embryo cDNA library that encodes a receptor protein kinase of the TGF-β receptor subfamily. The deduced amino acid sequence reveals the presence of a hydrophobic transmembrane helix and a kinase domain distantly related to type II receptor for TGF-β. The kinase domain sequence is most similar to RPK-1 identified recently in the chick embryo. Several cysteine residues are contained in the amino-terminal ectodomain, suggesting the protein as a receptor for a peptide growth factor of the TGF-β family.

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Nucleotide sequence of a cDNA encoding the chicken receptor protein kinase of the TGF-β receptor family

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Nucleotide sequence of a cDNA encoding the chicken receptor protein kinase of the TGF-β receptor family

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