Nucleotide Sequence of a Highly Conserved Region of the Canine p53 Tumour Suppressor Gene

L. Nasir Department of Veterinary Clinical Studies, University of Glasgow Veterinary School, Bearsden Road, G61 1QH, Scotland, UK

D. J. Argyle Department of Veterinary Clinical Studies, University of Glasgow Veterinary School, Bearsden Road, G61 1QH, Scotland, UK

S. T. McFarlane Department of Veterinary Clinical Studies, University of Glasgow Veterinary School, Bearsden Road, G61 1QH, Scotland, UK

S. W. J. Reid Department of Veterinary Clinical Studies, University of Glasgow Veterinary School, Bearsden Road, G61 1QH, Scotland, UK

Abstract

An evolutionary conserved region of the canine tumour suppressor gene, p53, was PCR amplified and its DNA sequence determined. The 1003 bp fragment consisted of exons 5 to 8 and the intervening introns. A high level of sequence homology was demonstrated with human sequences, with the evolutionary conserved domains II, III, IV and V being identical.

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Nucleotide Sequence of a Highly Conserved Region of the Canine p53 Tumour Suppressor Gene

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Nucleotide Sequence of a Highly Conserved Region of the Canine p53 Tumour Suppressor Gene

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