Atypical Chronic Myeloid Leukaemia with Trisomy 21 Mosaicism as a Sole Chromosomal Abnormality

D. Benedek First Department of Internal Medicine, University Hospital Köln, 50924, Köln

M. Kiehl Clinic for Bone Marrow Transplantation Haematology/Oncology, 55743, Idar-Oberstein, Germany

A. Draube First Department of Internal Medicine, University Hospital Köln, 50924, Köln

J. Chemnitz First Department of Internal Medicine, University Hospital Köln, 50924, Köln

V. Diehl First Department of Internal Medicine, University Hospital Köln, 50924, Köln

D. Söhngen First Department of Internal Medicine, University Hospital Köln, 50924, Köln

Abstract

We present a 46-year-old patient with Ph-chromosome negative, bcr-negative chronic myeloid leukaemia (CML) in accelerated phase with a clonal trisomy 21 in the leukaemic blast cells. A rapid progress of disease with appearance of monocytosis is described, showing similar features to chronic myelomonocytic leukaemia (CMML). Heterogeneous characteristics and possible distinction of these two entities are discussed.

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Atypical Chronic Myeloid Leukaemia with Trisomy 21 Mosaicism as a Sole Chromosomal Abnormality

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Atypical Chronic Myeloid Leukaemia with Trisomy 21 Mosaicism as a Sole Chromosomal Abnormality

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