Circulating and Tumor-Infiltrating γδ T Cells in Patients with B-Cell Lymphomas

Yuzuru Kuriyama First Department of Internal Medicine, Tokyo Medical University, 6-7-1, Nishishinjuku, Shinjuku-kit, Tokyo, 160-0023, Japan

Yoshikazu Kawanishi First Department of Internal Medicine, Tokyo Medical University, 6-7-1, Nishishinjuku, Shinjuku-kit, Tokyo, 160-0023, Japan

Masahiko Otawa First Department of Internal Medicine, Tokyo Medical University, 6-7-1, Nishishinjuku, Shinjuku-kit, Tokyo, 160-0023, Japan

Kenta Utsumi First Department of Internal Medicine, Tokyo Medical University, 6-7-1, Nishishinjuku, Shinjuku-kit, Tokyo, 160-0023, Japan

Kazuma Ohyashiki First Department of Internal Medicine, Tokyo Medical University, 6-7-1, Nishishinjuku, Shinjuku-kit, Tokyo, 160-0023, Japan

Abstract

In order to analyze the involvement of γδ T cells in the immune surveillance against B cell lymphomas (BCL), we investigated the proportion of circulating γδ T cells in 52 BCL patients using two-color flow cytometry, together with tumor-infiltrating γδ T cells in 22 of those patients. We found that the proportion of tumor-infiltrating γδ T cells in BCL patients was not different from that of lymph node γδ T cells in reactive hyperplasia patients. However, a decreased percentage of circulating γδ T cells were observed in indolent lymphoma (IL) and limited aggressive lymphoma (AL) patients when compared with normal controls. In contrast, as a result of a histogram. advanced AL patients were divided into two subgroups: the patients with increased circulating γδ T cells anti those without any increase. However, there was no difference in the clinical features of between the two AL subgroups.

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Circulating and Tumor-Infiltrating γδ T Cells in Patients with B-Cell Lymphomas

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Circulating and Tumor-Infiltrating γδ T Cells in Patients with B-Cell Lymphomas

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