Screening of Bcr-Abl Transcripts in Philadelphia Negative Essential Thrombocythemia

Mario Tiribelli Chair and Division of Hematology, Department of Medical and Morphological Research, University of Udine, Italy

Angela Michelutti Chair and Division of Hematology, Department of Medical and Morphological Research, University of Udine, Italy

Giuseppe Damantle Institute of Genetics, Department of Bio-medical Sciences and Technology, University of Udine, Italy

Lucia Pellizzari Institute of Genetics, Department of Bio-medical Sciences and Technology, University of Udine, Italy

Giovanni Martinelli Institute of Hematology and Oncology “L. e A. Seràgnoli”, University of Bologna, Italy

Marilina Amabile Institute of Hematology and Oncology “L. e A. Seràgnoli”, University of Bologna, Italy

Domenico Russo Chair and Division of Hematology, Department of Medical and Morphological Research, University of Udine, ItalyCorrespondence[email protected]

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Abstract

Essential thrombocythemia (ET) is a chronic myeloproliferative disorder characterised by the absence of the Philadelphia (Ph+) chromosome. Recent studies have reported controversial results relating to BCR-ABL rearrangements in ET patients. We studied 44 Ph-negative ET patients with the RT-PCR technique at diagnosis or during the follow-up. None of them showed any of the BCR-ABL. transcript actually described by others in ET; neither the “classical” P210 nor the P190 or P230 variants. Our results confirm the absence of BCR-ABL abnormalities in Ph-negative ET patients.

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Screening of Bcr-Abl Transcripts in Philadelphia Negative Essential Thrombocythemia

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Screening of Bcr-Abl Transcripts in Philadelphia Negative Essential Thrombocythemia

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