High Remission Rate in Acute Myeloblastic Leukemia with Only Two Days of Chemotherapy

Abstract

Twenty five patients with AML who had neither a history of toxic exposure or myelodysplasia were treated with a remission induction regimen consisting of two pulses of chemotherapy separated by 96 hrs. Each pulse consisted of cytarabine 2gm/m² (at t=0 and t=12 hrs) with mitoxantrone [30mg/m²] administered immediately after the second cytarabine administration. Amifostine was administered three times a week [on Monday, Wednesday, and Friday] until the outcome of therapy was known. This regimen induced complete remissions in 15 of 17 patients less than 70 years of age and in 5 of 8 patients older than 70 years.

Key Words:

• AML
• Remission Induction
• Amifostine