Hodgkin's Disease Complicated by the Nephrotic syndrome in a Man with Kugelberg-Welander Disease

Abstract

A case of nephrotic syndrome due to minimal change glomerulonephritis complicating Hodgkin's disease in a man with a longstanding neurological disorder is presented. Treatment with combination chemotherapy resulted in a rapid improvement in the nephrotic syndrome, and complete remission of the Hodgkin's disease. Disease relapse occurred less than 12 months later without recurrence of the nephrotic syndrome and was refractory to further treatment. The association of minimal change glomerulonephritis with Hodgkin's disease and the possible pathogenesis of this association are discussed.

Key Words:

• nephrotic syndrome
• minimal change glomerulonephritis
• Hodgkin's disease
• spinal muscular atrophy