“T-Cell-Rich B-Cell Lymphoproliferative Disorder” of the Bone Marrow

Abstract

We report four cases of a “T-cell-rich B-cell chronic lymphoproliferative disorder” involving the bone marrow and not extramedullary sites. The neoplastic B-cell proliferation in these cases was composed predominantly of small lymphoid cells with features of both hairy cell leukemia and lymphoplasmacytoid lymphoma. All cases presented with neutropenia and with difficulty in diagnosis. We present the clinical, morphologic, cytochemical, and immunophenotypic findings in these cases and discuss this entity.

Key Words:

• T-cell-rich B-cell chronic lymphoproliferative disorder
• bone marrow