The function of cyclic-adenosine monophosphate responsive element-binding protein in hematologic malignancies

Abstract

Central to discovering novel approaches to treating leukemias and lymphomas is a clear understanding of the signaling networks which lead to unchecked cell cycle progression, proliferation, and survival. Cyclic-adenosine monophosphate (cAMP) responsive element-binding protein (CREB) represents a critical integrator of numerous signals from cytoplasmic kinase cascades, and is directly involved in controlling the transcription of genes critical for normal cellular proliferation and survival. Several lines of evidence implicate CREB as a proto-oncogene, as a number of translocations involving CREB and dysregulation of expression are both associated with oncogenesis. Thus, CREB represents a potential therapeutic target in leukemia. Here, we review CREB function and regulation in normal and aberrant hematopoiesis.

Keywords::

• Transcription factor changes
• cell cycle and apoptosis changes
• lymphoid leukemia
• myeloid leukemias and dysplasias
• signal transduction

Acknowledgement

Grant support for this paper was provided by 5R01HL083077, 2R01HL075826, and 5T32HL086345.

Potential conflict of interest:

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