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Abstract
Inflammation and cancer are two independent biological events that can play an interdependent role. The model of such interaction is represented by Hodgkin lymphoma (HL), where the microenvironment is dominated by an extensive mixed, potentially cellular inflammatory infiltrate that plays a decisive role in the pathobiology of HL. In this review we summarize updated information on the complex interactions between Hodgkin Reed–Sternberg (HRS) cells and their tissue microenvironment, highlighting the functional role of CD40/CD40L and interferon regulatory factor 4 (IRF4).
Acknowledgements
This work was supported in part by the Associazione Italiana per la Ricerca sul Cancro (A.I.R.C.), Milan, Italy; the Ministero della Salute, Ricerca Finalizzata FSN, I.R.C.C.S., Rome, Italy; and by grants from the Ministero della Salute, Rome, within the framework of the “Progetto Integrato Oncologia-Advanced Molecular Diagnostics” project (RFPS-2006-2-339694.1; RFPS-2006-2-339723.2).
Potential conflict of interest:
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