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Research Articles

Clinical evaluation of WT1 mRNA expression levels in peripheral blood and bone marrow in patients with myelodysplastic syndromes

Yasunori UedaDepartment of Hematology/Oncology, Transfusion and Hemapheresis Center, Kurashiki Central Hospital, Okayama, JapanCorrespondence[email protected]

Chisato MizutaniDepartment of Hematology/Oncology, Transfusion and Hemapheresis Center, Kurashiki Central Hospital, Okayama, Japan

Yasuhito NannyaDepartment of Hematology and Oncology, University of Tokyo Graduate School of Medicine, Tokyo, Japan

Mineo KurokawaDepartment of Hematology and Oncology, University of Tokyo Graduate School of Medicine, Tokyo, Japan

Sumiko KobayashiDepartment of Hematology and Rheumatology, Nihon University School of Medicine, Tokyo, Japan

Jin TakeuchiDepartment of Hematology and Rheumatology, Nihon University School of Medicine, Tokyo, Japan

Hideto TamuraDivision of Hematology, Department of Medicine, Nippon Medical School, Tokyo, Japan

Kiyoyuki OgataDivision of Hematology, Department of Medicine, Nippon Medical School, Tokyo, Japan

Kazuo DanDivision of Hematology, Department of Medicine, Nippon Medical School, Tokyo, Japan

Hirohiko ShibayamaDepartment of Hematology and Oncology, Osaka University Graduate School of Medicine, Osaka, Japan

Yuzuru KanakuraDepartment of Hematology and Oncology, Osaka University Graduate School of Medicine, Osaka, Japan

Keiko NiimiDepartment of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan

Ko SasakiDepartment of Hematology and Oncology, Dokkyo Medical University Hospital, Tochigi, Japan

Masato WatanabeDepartment of Hematology, Fujita Health University School of Medicine, Aichi, Japan

Nobuhiko EmiDepartment of Hematology, Fujita Health University School of Medicine, Aichi, Japan

Masanao TeramuraDepartment of Hematology, Tokyo Women's Medical University, Tokyo, Japan

Toshiko MotojiDepartment of Hematology, Tokyo Women's Medical University, Tokyo, Japan

Michiko KidaDivision of Hematology, NTT Kanto Medical Center, Tokyo, Japan

Kensuke UsukiDivision of Hematology, NTT Kanto Medical Center, Tokyo, Japan

Satoru TakadaDepartment of Hematology, Saiseikai Maebashi Hospital, Gunma, Japan

Toru SakuraDepartment of Hematology, Saiseikai Maebashi Hospital, Gunma, Japan

Yoshikazu ItoDivision of Hematology, Tokyo Medical University Hospital, Tokyo, Japan

Kazuma OhyashikiDivision of Hematology, Tokyo Medical University Hospital, Tokyo, Japan

Hiroyasu OgawaDivision of Hematology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo, Japan

Takahiro SuzukiDivision of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan

Keiya OzawaDivision of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan

Kiyotoshi ImaiDepartment of Hematology, Sapporo Hokuyu Hospital, Sapporo, Japan

Masaharu KasaiDepartment of Hematology, Sapporo Hokuyu Hospital, Sapporo, Japan

Tomoko HataDepartment of Hematology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

Yasushi MiyazakiDepartment of Hematology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

Yasuyoshi MoritaDivision of Hematology, Kinki University School of Medicine, Osaka, Japan

Akihisa KanamaruDivision of Hematology, Kinki University School of Medicine, Osaka, Japan

Akira MatsudaDepartment of Hemato-Oncology, Saitama International Medical Center, Saitama Medical University, Saitama, Japan

Kaoru TohyamaDepartment of Laboratory Medicine, Kawasaki Medical School, Okayama, Japan

Daisuke KogaDiagnostic Division, Otsuka Pharmaceutical Co., Ltd., Tokushima, Japan

Hiroya TamakiDivision of Hematology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo, Japan

Kinuko MitaniDepartment of Hematology and Oncology, Dokkyo Medical University Hospital, Tochigi, Japan

Tomoki NaoeDepartment of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan

Haruo SugiyamaDepartment of Functional Diagnostic Science, Osaka University Graduate School of Medicine, Osaka, Japan

Fumimaro TakakuJichi Medical University, Tochigi, Japan

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Abstract

A study to evaluate WT1 mRNA expression levels in peripheral blood (PB) and bone marrow aspirate (BM) was conducted in 172 patients, including 115 with myelodysplastic syndromes (MDS), in Japan. The level of WT1 mRNA expression was evaluated according to the French–American–British (FAB) and World Health Organization (WHO) classifications (2001, 2008) and using the International Prognostic Scoring System and the WHO Prognostic Scoring System scales. WT1 mRNA expression levels in PB and BM were well correlated (r = 0.85), and they tended to increase with disease stage progression and in those at higher risk of leukemic transformation. WT1 mRNA expression can be a useful marker for the diagnosis and risk evaluation of MDS.

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Clinical evaluation of WT1 mRNA expression levels in peripheral blood and bone marrow in patients with myelodysplastic syndromes

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Clinical evaluation of WT1 mRNA expression levels in peripheral blood and bone marrow in patients with myelodysplastic syndromes

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