Potential role of curcumin and taurine combination therapy on human myeloid leukemic cells propagated in vitro

Abstract

Curcumin and taurine are natural products that have been used in this study evaluating their therapeutic effect on myeloid leukemic cells propagated in vitro. Sixty patients with myeloid leukemia and 30 healthy volunteers were enrolled in the study. All patient groups were admitted to the Medical Oncology Department of the National Cancer Institute, Cairo University. There were statistically significant differences between treated leukemic cells compared to normal mononuclear leukocytes in cell density, interferon-γ and immunophenotypic profile, mainly CD4+, CD8 + and CD25+. This work highlights the possibility of using curcumin and taurine as a potential useful therapy in the management of patients suffering from chronic and acute myeloid leukemias.

Keywords::

• Acute myeloid leukemia (AML)
• chronic myeloid leukemia (CML)
• curcumin–taurine
• immunophenotypic profile
• interferon-γ

Acknowledgements

This work was supported in part by the Cancer Biology Department, National Cancer Institute (NCI), Cairo University and the Biochemistry Department, Faculty of Science, Cairo University.

Potential conflict of interest:

Disclosure forms provided by the authors are available with the full text of this article at www.informahealthcare.com/lal.