Relationship between 2-deoxy-2-[¹⁸F]-fluoro-d-glucose uptake and clinicopathological factors in patients with diffuse large B-cell lymphoma

Abstract

The aim of this study was to investigate correlations between the standardized uptake value of the biopsy site (BSUV_max) and levels of glucose transporter (GLUT)-1, GLUT-3 and hexokinase-II (HK-II), between BSUV_max and the Ki-67 proliferation index (MIB-1), and between BSUV_max and clinicopathological factors. Sixty-eight patients with diffuse large B-cell lymphoma (DLBCL) were included in this study. BSUV_max was significantly correlated with GLUT-1, GLUT-3 and the International Prognostic Index (IPI) (GLUT-1: r = 0.584, IPI: r = 0.363, p < 0.001; GLUT-3: r = 0.369, p = 0.009; IPI: r = 0.363, p = 0.004), but not with MIB-1 and HK-II. A statistically significant correlation was observed between GLUT-3 expression and each of IPI and gene expression profiling (GEP) (IPI: p = 0.0186; GEP: p = 0.0179). 2-Deoxy-2-[¹⁸F]-fluoro-d-glucose (FDG) uptake was significantly correlated with the levels of GLUT-1 and GLUT-3 and with IPI. The results indicated that GLUT-3 expression is related to GEP and IPI, and that BSUV_max and GLUT-3 may have a relationship with the prognosis of DLBCL.

Keywords::

• Diffuse large B-cell lymphoma
• FDG-PET
• glucose transporter
• hexokinase-II
• International Prognostic Index

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