Transplant Related Septicaemia in Patients Undergoing Autologous Bone Marrow Transplantation for Lymphoma and Acute Leukaemia

Seah H. Lim Departments of Haematology, University College Hospital, Gower Street, London, England, UK

Andrew K. McMillan Departments of Haematology, University College Hospital, Gower Street, London, England, UK

Raj Chopra Departments of Haematology, University College Hospital, Gower Street, London, England, UK

Sally E. Kinsey Departments of Haematology, University College Hospital, Gower Street, London, England, UK

Paul Cervi Departments of Haematology, University College Hospital, Gower Street, London, England, UK

Nina Salooja Departments of Haematology, University College Hospital, Gower Street, London, England, UK

Mark P. Smith Departments of Haematology, University College Hospital, Gower Street, London, England, UK

John Holton Microbiology, University College Hospital, Gower Street, London, England, UK

David C. Linch Departments of Haematology, University College Hospital, Gower Street, London, England, UK

Anthony H. Goldstone Departments of Haematology, University College Hospital, Gower Street, London, England, UK

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Abstract

193 consecutive adult patients undergoing autologous bone marrow transplantation (ABMT) for lymphomas and acute leukaemias were studied retrospectively to investigate the pattern of peri-transplant septicaemia. 80% of the early peri-transplant septicaemia occurred between day 4 and day 10 after AMBT. Gram-positive septicaemia was significantly more frequent than gram-negative septicaemia. The immediate mortality rate due to septicaemia during the early post-transplant period (< 72 hours from the development of first febrile episode), whether gram-negative or gram-positive was low (1%). Most infective deaths occurred in patients undergoing ABMT for primary refractory or resistant relapsed lymphomas and as a result of pulmonary complications presumed but not always confirmed to be of infective origin.

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Transplant Related Septicaemia in Patients Undergoing Autologous Bone Marrow Transplantation for Lymphoma and Acute Leukaemia

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Transplant Related Septicaemia in Patients Undergoing Autologous Bone Marrow Transplantation for Lymphoma and Acute Leukaemia

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