Chromosome 1p Abnormalities in B Non Hodgkin's Lymphoma

Elisabeth van den Berghe Centre for Human Genetics, AZ St. Jan, Brugge, Belguim

Chris de Wolf-peeters Department of Pathology, AZ St. Jan, Brugge, Belguim

Andries Louwagie Department of Hematology, AZ St. Jan, Brugge, Belguim

JosÉ Thomas Department of Oncology, University of Leuven, Leuven, Belguim

Iwona Wlodarska Centre for Human Genetics, AZ St. Jan, Brugge, Belguim

Paola Dal Cin Centre for Human Genetics, AZ St. Jan, Brugge, Belguim

Michel Stul Centre for Human Genetics, AZ St. Jan, Brugge, Belguim

Jean-Jacques Cassiman Centre for Human Genetics, AZ St. Jan, Brugge, Belguim

Cristina Mecucci Centre for Human Genetics, AZ St. Jan, Brugge, Belguim

Herman van den Berghe Centre for Human Genetics, AZ St. Jan, Brugge, Belguim

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Abstract

Thirteen patients with B-non Hodgkin's lymphoma and abnormalities of the short arm of chromosome 1 were evaluated, to see if this cytogenetic anomaly was associated with a particular subgroup of lymphomas. Large cell lymphoma was found in seven patients (with an immunoblastic component in four cases). Six patients with diffuse small cleaved cell lymphoma of non follicle centre cell origin formed a second group. The chromosome 1 breakpoints in the second group were located between p34 and p36, suggesting that genes located here may be important in the initiation or progression of these lymphomas.

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Chromosome 1p Abnormalities in B Non Hodgkin's Lymphoma

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Chromosome 1p Abnormalities in B Non Hodgkin's Lymphoma

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