Chronic Myeloid Leukemia Following Radioactive Iodine ¹³¹I Therapy of Thyroid Cancer

Abstract

We describe a 51 years old female patient who developed Ph¹ positive chronic myeloid leukemia 7 years following radioactive iodine therapy for follicular carcinoma of thyroid. Until now, only two patients have been reported to have developed CML after this kind of therapy. The underlying mechanisms are discussed and the need to study such patients at cytogenetic, molecular biologic and cell kinetic levels is stressed.

Key Words:

• Chronic myeloid leukemia
• radioactive iodine
• therapy for thyroid cancer
• Iodine¹³¹ induced CML