Cytokines in B-Cell Chronic Lymphocytic Leukemia

R. Foa Dipartimento di Scienze Biomediche ed Oncologia Umana, Sezione di Clinica Medica, and Centro CNR “Immunogenetica ed Istocompatibilitá”, University of Torino, Italy

A. Gillio Tos Dipartimento di Scienze Biomediche ed Oncologia Umana, Sezione di Clinica Medica, and Centro CNR “Immunogenetica ed Istocompatibilitá”, University of Torino, Italy

P. Francia di Celle Dipartimento di Scienze Biomediche ed Oncologia Umana, Sezione di Clinica Medica, and Centro CNR “Immunogenetica ed Istocompatibilitá”, University of Torino, Italy

A. Carbone Dipartimento di Scienze Biomediche ed Oncologia Umana, Sezione di Clinica Medica, and Centro CNR “Immunogenetica ed Istocompatibilitá”, University of Torino, Italy

D. Marchis Dipartimento di Scienze Biomediche ed Oncologia Umana, Sezione di Clinica Medica, and Centro CNR “Immunogenetica ed Istocompatibilitá”, University of Torino, Italy

F. Vischia Dipartimento di Scienze Biomediche ed Oncologia Umana, Sezione di Clinica Medica, and Centro CNR “Immunogenetica ed Istocompatibilitá”, University of Torino, Italy

A. Cignetti Dipartimento di Scienze Biomediche ed Oncologia Umana, Sezione di Clinica Medica, and Centro CNR “Immunogenetica ed Istocompatibilitá”, University of Torino, Italy

A. Guarini Dipartimento di Scienze Biomediche ed Oncologia Umana, Sezione di Clinica Medica, and Centro CNR “Immunogenetica ed Istocompatibilitá”, University of Torino, Italy

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Abstract

The pleomorphic action of different cytokines in regulating the growth and proliferation of normal B- and T-lymphocyte populations is becoming progressively more apparent. Thus, the possibility that some cytokines, either alone or in variable combination, may play a role in different lymphoproliferative disorders has been increasingly suggested and potential autocrine or paracrine loops hypothesized. Here, we shall discuss some of the known B-cell growth factors which have been postulated to be involved in the hematological progression, clinical course and complications in B-cell lymphocytic leukemia.

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Cytokines in B-Cell Chronic Lymphocytic Leukemia

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Cytokines in B-Cell Chronic Lymphocytic Leukemia

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