Letter: Prognosis in Acute Lymphoblastic Leukemia (ALL) in Children Preceded by an Aplastic Phase

Jerzy Armata Department of Hematology, Polish-American Children's Hospital, Nicolaus Copernicus University School of Medicine, 265 Wielicka St. 30-663, Krakéw, Poland

Julita Grześkowiak-Melanowska Department of Hematology, Polish-American Children's Hospital, Nicolaus Copernicus University School of Medicine, 265 Wielicka St. 30-663, Krakéw, Poland

Walentyna Balwierz Department of Hematology, Polish-American Children's Hospital, Nicolaus Copernicus University School of Medicine, 265 Wielicka St. 30-663, Krakéw, Poland

Anna Najbar-Pabian Department of Hematology, Polish-American Children's Hospital, Nicolaus Copernicus University School of Medicine, 265 Wielicka St. 30-663, Krakéw, Poland

Ewa Pawlik-Niesytto Department of Hematology, Polish-American Children's Hospital, Nicolaus Copernicus University School of Medicine, 265 Wielicka St. 30-663, Krakéw, Poland

Abstract

Sir, It is now well known that aplastic anemia (AA) may represent a phase preceding ALL (pre-ALL). Despite numerous reports on this subject including more than 40 reported cases^1-9 the etiology and pathogenesis of pre-ALL has not been adequately explained. Out of 552 children treated in our department for ALL during 1969-1992, pre-ALL has only been detected in eight patients (1.5%). The table summarizes our material.

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Letter: Prognosis in Acute Lymphoblastic Leukemia (ALL) in Children Preceded by an Aplastic Phase

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Letter: Prognosis in Acute Lymphoblastic Leukemia (ALL) in Children Preceded by an Aplastic Phase

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