Clonal Analysis of Hodgkin's Disease Shows Absence of TCR/Ig Gene Rearrangement, Compared with T-Cell-Rich B-Cell Lymphoma and Incipient Adult T-Cell Leukemia/Lymphoma

Koichi Ohshima Department of Pathology and Internal Medicine, School of Medicine, Fukuoka University, Fukuoka, Japan

Masahiro Kikuchi Department of Pathology and Internal Medicine, School of Medicine, Fukuoka University, Fukuoka, Japan

Takao Shibata Department of Pathology and Internal Medicine, School of Medicine, Fukuoka University, Fukuoka, Japan

Yoshiaki Sumiyoshi Department of Pathology and Internal Medicine, School of Medicine, Fukuoka University, Fukuoka, Japan

Shinichi Kobari Department of Pathology and Internal Medicine, School of Medicine, Fukuoka University, Fukuoka, Japan

Satoshi Yoneda Department of Pathology and Internal Medicine, School of Medicine, Fukuoka University, Fukuoka, Japan

Morishige Takeshita Department of Pathology and Internal Medicine, School of Medicine, Fukuoka University, Fukuoka, Japan

Nobuhiro Kimura Department of Pathology and Internal Medicine, School of Medicine, Fukuoka University, Fukuoka, Japan

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Abstract

To better characterize the clonality and pathogenesis of Hodgkin's disease (HD), we used polymerase chain reaction (PCR) and Southern blot to analyze the rearrangement of immunoglobulin (Ig) and T-cell receptor (TCR) genes, the bcl-2 oncogene, and the Epstein-Barr virus (EBV) genotype. In situ hybridization studies of EBV were also done. Twenty-six cases of HD were compared with 15 cases of non-specific lymphadenitis, 7 with incipient adult T-cell leukemia/lymphoma (ATLL), and 4 T-cell rich B-cell lymphomas (TRBL), all of which histologically resembled HD.

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Clonal Analysis of Hodgkin's Disease Shows Absence of TCR/Ig Gene Rearrangement, Compared with T-Cell-Rich B-Cell Lymphoma and Incipient Adult T-Cell Leukemia/Lymphoma

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Clonal Analysis of Hodgkin's Disease Shows Absence of TCR/Ig Gene Rearrangement, Compared with T-Cell-Rich B-Cell Lymphoma and Incipient Adult T-Cell Leukemia/Lymphoma

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