Polymyositis Associated with Ki-1 Lymphoma

Didier Bouscary Departments of Hematology, Internal Medicine and Pathology, Cochin, Paris

Micheline Tulliez Hospital, Cochin, Paris

Francois Dreyfus Departments of Hematology, Internal Medicine and Pathology, Cochin, Paris

Martine Raphael Department of Hematology, Hospital PitieA SalpeAtrieGre, Paris

Olivier Hermine Department of Hematology, Hospital Necker, Paris

Francoise Picard Departments of Hematology, Internal Medicine and Pathology, Cochin, Paris

Georges Delsol Department of Pathology, Hospital Purpan, Toulouse, France

Didier Sicard Departments of Hematology, Internal Medicine and Pathology, Cochin, Paris

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Abstract

We report here a case of acute polymyositis associated with a Ki-1 non Hodgkin's lymphoma (NHL). This anaplastic large cell malignant lymphoma was a primary T-cell NHL lymphoma of the bone marrow. The malignant cells expressed the CD30 (Ki-1), CD3, and CD4 antigens, the beta chain of the interleukin 2 receptor (CD25), and the betaF1 antigen (alpha/beta T-cell receptor). Chemotherapy and high dose methylprednisolone pulse therapy were initiated. However, no clinical improvement was noticed, because the patient rapidly died of an acute respiratory distress syndrome. To our best knowledge, this represents the first case of Ki-1 lymphoma associated with Polymyositis.

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Polymyositis Associated with Ki-1 Lymphoma

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Polymyositis Associated with Ki-1 Lymphoma

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