Extramedullary Megakaryoblastic Tumors Following an Indolent Phase of Myelofibrosis

Akihiko Chubachi Third Department of Internal Medicine, First Department of Pathology, Akita University School of Medicine, and Department of Internal Medicine, Yuri Kumiai General Hospital, Akita, Japan

Hideki Wakui Third Department of Internal Medicine, First Department of Pathology, Akita University School of Medicine, and Department of Internal Medicine, Yuri Kumiai General Hospital, Akita, Japan

Ikuo Miura Third Department of Internal Medicine, First Department of Pathology, Akita University School of Medicine, and Department of Internal Medicine, Yuri Kumiai General Hospital, Akita, Japan

Masahiro Saitoh Third Department of Internal Medicine, First Department of Pathology, Akita University School of Medicine, and Department of Internal Medicine, Yuri Kumiai General Hospital, Akita, Japan

Tamio Nishinari Third Department of Internal Medicine, First Department of Pathology, Akita University School of Medicine, and Department of Internal Medicine, Yuri Kumiai General Hospital, Akita, Japan

Shigeki Nishimura Third Department of Internal Medicine, First Department of Pathology, Akita University School of Medicine, and Department of Internal Medicine, Yuri Kumiai General Hospital, Akita, Japan

Akira B. Miura Third Department of Internal Medicine, First Department of Pathology, Akita University School of Medicine, and Department of Internal Medicine, Yuri Kumiai General Hospital, Akita, Japan

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Abstract

A 59-year-old man developed multiple subcutaneous and bone tumors after 2 years' duration of indolent myelofibrosis. These tumors exhibited a diffuse proliferation of pleomorphic blast cells. The skeletal x-rays showed disseminated osteolysis and osteosclerosis. Blast cells obtained from the pleural effusion did not react with myeloperoxidase, sudan black B or non-specific esterase. Genotypic analysis of DNA samples at autopsy did not demonstrate rearrangements of T-cell receptor β-chain or immunoglobulin heavy-chain genes. Frozen-section immunohistochemical studies revealed that the neoplastic cells were derived from megakaryocytic lineage. The present case represents a novel and unusual subtype of megakaryocytic neoplasm.

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Extramedullary Megakaryoblastic Tumors Following an Indolent Phase of Myelofibrosis

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Extramedullary Megakaryoblastic Tumors Following an Indolent Phase of Myelofibrosis

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